Here is an infographic showing the current variants of concern and the subsequent data on the vaccines. We currently have lab based data available, but expecting to see human trial data shortly. We do not expect to see as drastic a decrease (eg 6 fold) in efficacy given that neutralizing antibodies are only one component of the adaptive immune system and that memory B and T cells also play an important role. In prelim data, we see that Memory B and T cells are not as drastically impacted by the E484K mutation. Will be updated as new info becomes available.